Association of progesterone receptor polymorphism with recurrent abortions.

  title={Association of progesterone receptor polymorphism with recurrent abortions.},
  author={Andreas Schweikert and T. Rau and Alexander Berkholz and Axel All{\'e}ra and Sabine Daufeldt and Ludwig Wildt},
  journal={European journal of obstetrics, gynecology, and reproductive biology},
  volume={113 1},
OBJECTIVE The current study sought for polymorphisms within the progesterone receptor (PR) gene. Allele and genotype frequencies of patients with repeated abortions were compared to a control group. DESIGN All exons of the PR of 42 women with repeated abortions and 40 controls were screened for single nucleotide polymorphisms (SNP). Determination of the DNA-sequences was performed. RESULTS Three SNPs were detected (exon 1: G1031C Ser344Thr; exon 4: G1978T Leu660Val, exon 5: C2310T His770His… CONTINUE READING


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