Association of polymorphisms within androgen receptor, 5alpha-reductase, and PSA genes with prostate volume, clinical parameters, and endocrine status in elderly men.

@article{Schatzl2002AssociationOP,
  title={Association of polymorphisms within androgen receptor, 5alpha-reductase, and PSA genes with prostate volume, clinical parameters, and endocrine status in elderly men.},
  author={Georg Schatzl and Stephan Madersbacher and Andrea Gsur and Martin Preyer and Gerald Haidinger and Andrea Haitel and Christian Vutuc and Michael Micksche and Michael J Marberger},
  journal={The Prostate},
  year={2002},
  volume={52 2},
  pages={130-8}
}
BACKGROUND The aim of this study was to assess the impact of polymorphisms of three genes within the androgen pathway on prostate volume, clinical parameters, and endocrine status. METHODS Elderly men with lower urinary tract symptoms underwent clinical and endocrine work-up. In parallel, polymorphisms within the 5alpha-reductase gene (SRD5A2 V89L and A49T), the androgen receptor gene (AR; number of CAG repeats), and the prostate specific antigen (PSA) gene (A --> G substitution at position… CONTINUE READING
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