Association of polymorphisms of the osteoprotegerin gene with bone mineral density in Japanese women but not men.

@article{Yamada2003AssociationOP,
  title={Association of polymorphisms of the osteoprotegerin gene with bone mineral density in Japanese women but not men.},
  author={Yoshiji Yamada and Fujiko Ando and Naoakira Niino and Hiroshi Shimokata},
  journal={Molecular genetics and metabolism},
  year={2003},
  volume={80 3},
  pages={
          344-9
        }
}
Given that osteoprotegerin plays an important role in bone remodeling, the osteoprotegerin gene may be a candidate locus for susceptibility to osteoporosis. The relation of polymorphisms in the promoter of the osteoprotegerin gene to bone mineral density (BMD) was examined in a Japanese population-based prospective cohort study with randomly recruited subjects (1095 women and 1125 men for the 950T --> C polymorphism, 1094 women and 1127 men for the 245T --> G polymorphism). BMD at the radius… Expand
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The data indicated that the A allele of the g.27563G>A genetic polymorphism in OPG could be associated with lower BMD values in the Chinese postmenopausal women evaluated, and that it might be an increased risk factor for osteoporosis. Expand
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Findings suggeste that OPG gene variants are related to BMD and osteoporosis in Chinese postmenopausal women. Expand
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References

SHOWING 1-10 OF 31 REFERENCES
Polymorphisms in the Osteoprotegerin Gene Are Associated With Osteoporotic Fractures
TLDR
It is found that OPG is a candidate gene for genetic control of bone mass and the rare alleles of the A163‐G and T245‐G were significantly more common among patients with vertebral fractures. Expand
Sequence variations in the osteoprotegerin gene promoter in patients with postmenopausal osteoporosis.
TLDR
The results suggest that 209 G-->A and 245 T-->G polymorphisms in the OPG gene promoter may contribute to the genetic regulation of BMD. Expand
Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women.
TLDR
The COLIA1 polymorphism is associated with reduced bone density and predisposes women to osteoporotic fractures. Expand
Association of a polymorphism of the matrix metalloproteinase-1 gene with bone mineral density.
TLDR
The MMP-1 gene may be a susceptibility locus for reduced BMD at the distal radius in postmenopausal women with the GG/GG genotype. Expand
Investigation of the Genetic Influence of the OPG, VDR (Fok1), and COLIA1 Sp1 Polymorphisms on BMD in the Irish Population
TLDR
A lack of association between the VDR (fok1) polymorphism or COLIA1 Sp1 polymorphism and low BMD in either postmenopausal or premenopausal women in this population is found. Expand
Linkage and association analyses of the osteoprotegerin gene locus with human osteoporosis
TLDR
Although no evidence of significant linkage between OPG and osteoporosis was found, a possible association of one SNP, located in the promoter region of the gene, was identified and a haplotype analysis revealed that four major haplotypes account for 71% of the alleles in the Japanese population. Expand
Prediction of bone density from vitamin D receptor alleles
TLDR
It is shown that common allelic variants in the gene encoding the vitamin D receptor can be used to predict differences in bone density, accounting for up to 75% of the total genetic effect on bone density in healthy individuals. Expand
The Effect of a Single Dose of Osteoprotegerin in Postmenopausal Women
TLDR
This study indicates that a single sc injection of OPG is effective in rapidly and profoundly reducing bone turnover for a sustained period and that OPG therefore may be effective in treatment of bone diseases characterized by increased bone resorption such as osteoporosis. Expand
Genetic determinants of bone mass in adults. A twin study.
TLDR
The lesser genetic contribution to proximal femur and distal forearm bone mass compared with the spine suggests that environmental factors are of greater importance in the aetiology of osteopenia of the hip and wrist. Expand
Osteoprotegerin deficiency and juvenile Paget's disease.
TLDR
Juvenile Paget's disease can result from osteoprotegerin deficiency caused by homozygous deletion of TNFRSF11B, and serum levels of osteoclast differentiation factor were undetectable and markedly increased, respectively. Expand
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