Association of polymorphisms of leptin, leptin receptor and apelin receptor genes with susceptibility to coronary artery disease and hypertension.

@article{Nowzari2018AssociationOP,
  title={Association of polymorphisms of leptin, leptin receptor and apelin receptor genes with susceptibility to coronary artery disease and hypertension.},
  author={Zohreh Nowzari and Mohammad Masoumi and Mahdieh Nazari-Robati and Hamed Akbari and Nader Shahrokhi and Gholamreza Asadikaram},
  journal={Life sciences},
  year={2018},
  volume={207},
  pages={
          166-171
        }
}
AIMS Apelin and leptin are factors which have a potential physiological and pathological role in cardiovascular homoeostasis. Apelin receptor (APLNR), leptin receptor (LEPR) and leptin variants may affect the vascular tone in heart or peripheral circulation, thereby predisposing patients to hypertension and coronary artery disease (CAD). The aim of the present study was to evaluate four single nucleotide polymorphisms (SNPs) of APLNR genes (rs11544374 and rs948847), LEPR (rs1137101) and leptin… CONTINUE READING
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