Association of polymorphisms of dopamine D2 receptor (DRD2), and dopamine transporter (DAT1) genes with schizoid/avoidant behaviors (SAB)

@article{Blum1997AssociationOP,
  title={Association of polymorphisms of dopamine D2 receptor (DRD2), and dopamine transporter (DAT1) genes with schizoid/avoidant behaviors (SAB)},
  author={Kenneth Blum and Eric R. Braverman and Sujihan Wu and J G Cull and Tai Jui Chen and Jay S. Gill and Robert B. Wood and Andrew Eisenberg and Marta Sherman and Karl R Davis and Derek Matthews and Lorie Fischer and Nancy Schnautz and W. A. G. Walsh and Anneliese A. Pontius and M Zedar and Gilbert R. Kaats and David E. Comings},
  journal={Molecular Psychiatry},
  year={1997},
  volume={2},
  pages={239-246}
}
The dopaminergic system, and in particular the dopamine D2 receptor, has been implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance-seeking behaviors (ethanol, drugs, tobacco, and food) and other related behaviors (pathological gambling, Tourette's disorder, attention-deficit/hyperactivity disorder). This is the first study supporting a strong association between the dopamine D2 receptor Taq A1 allele with schizoid/avoidant behavior… CONTINUE READING