Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.

  title={Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.},
  author={Megan E. Rudock and Yongmei Liu and Julie T. Ziegler and Stewart Allen and Allison B. Lehtinen and Barry I. Freedman and Jeffrey J. Carr and Carl D. Langefeld and Donald W. Bowden},
  volume={203 2},
BACKGROUND Cardiovascular disease is the leading cause of death among Americans. Inflammation is a hallmark of the development of atherosclerosis and is mediated by prostaglandins, catalyzed by cyclooxygenase (COX)-2. We sought to determine if variants in the COX-2 gene were associated with subclinical measures of cardiovascular disease in a primarily type 2 diabetic population. METHODS Eight polymorphisms in COX-2 were genotyped and vascular calcified plaque measured in the coronary, carotid… CONTINUE READING
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