Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.

@article{Rudock2009AssociationOP,
  title={Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.},
  author={Megan E. Rudock and Yongmei Liu and Julie T. Ziegler and Stewart Allen and Allison B. Lehtinen and Barry I. Freedman and Jeffrey J. Carr and Carl D. Langefeld and Donald W. Bowden},
  journal={Atherosclerosis},
  year={2009},
  volume={203 2},
  pages={459-65}
}
BACKGROUND Cardiovascular disease is the leading cause of death among Americans. Inflammation is a hallmark of the development of atherosclerosis and is mediated by prostaglandins, catalyzed by cyclooxygenase (COX)-2. We sought to determine if variants in the COX-2 gene were associated with subclinical measures of cardiovascular disease in a primarily type 2 diabetic population. METHODS Eight polymorphisms in COX-2 were genotyped and vascular calcified plaque measured in the coronary, carotid… CONTINUE READING
Highly Cited
This paper has 87 citations. REVIEW CITATIONS
14 Citations
32 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

87 Citations

0102030'10'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 87 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 32 references

A comparison of risk factors for calcified atherosclerotic plaque in the coronary , carotid , and abdominal aortic arteries : The Diabetes Heart Study

  • RC Detrano, M Anderson, +4 authors DE Bild
  • Am J Epidemiol
  • 2007

Cyclooxygenase polymorphisms risk of cardiovascular events : The Atherosclerosis Risk in Communities ( ARIC ) Study

  • J Orbe, O Beloqui, JA Rodriguez
  • Clin Pharmacol Ther
  • 2007

Heart disease and stroke statistics —

  • K Flegal, G Friday
  • 2007

Risk in Communities Study

  • CR Lee, KE North, BrayMS
  • 2007

Protective effect of the G - 765 C COX - 2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors

  • YL Konheim, JK Wolford
  • Clin Chim Acta
  • 2006

Similar Papers

Loading similar papers…