Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin-to-creatinine ratio.

@article{Ururahy2015AssociationOP,
  title={Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin-to-creatinine ratio.},
  author={Marcela Abbott Galv{\~a}o Ururahy and Karla Simone Costa de Souza and Yonara Monique da Costa Oliveira and Melina Bezerra Loureiro and Heglayne Pereira Vital da Silva and Francisco Paulo Freire-Neto and Jo{\~a}o Bezerra and Andr{\'e} Ducati Luchessi and Sonia de Quateli Doi and Rosario Dominguez Crespo Hirata and Maria das Graças Almeida and Ricardo Fernando Arrais and M{\'a}rio Hiroyuki Hirata and Adriana A de Rezende},
  journal={Diabetes/metabolism research and reviews},
  year={2015},
  volume={31 5},
  pages={500-6}
}
BACKGROUND Pro-inflammatory cytokines, such as interleukin-6 (IL-6), have been considered as key factors in type 1 diabetes mellitus (T1DM) and diabetic nephropathy, thus, our aim was to investigate the association of IL6-174G>C (rs1800795) and -634C>G (rs1800796) polymorphisms with T1DM susceptibility and diabetic nephropathy. METHODS These polymorphisms were analyzed in 144 children and adolescents with T1DM and 173 normoglycemic control subjects. Glycemic control, laboratory parameters of… CONTINUE READING

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