Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families.

@article{Graham2007AssociationOP,
  title={Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families.},
  author={D S Cunninghame Graham and Mohammed Akil and Timothy J Vyse},
  journal={Rheumatology},
  year={2007},
  volume={46 6},
  pages={927-30}
}
OBJECTIVES This is a family-based association study to investigate the genetic contribution of tyrosine kinase 2 (TYK2 ) to disease susceptibility in 380 UK systemic lupus erythematosus (SLE) families, consisting of parents and affected offspring. METHODS Genotyping was performed using the Sequenom platform on DNA from affected individuals and their parents. Haplotypes were constructed using Haploview from the founders, and family-based association was conducted using GENEHUNTER-TDT and… CONTINUE READING

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