Association of polymorphism of the p22PHOX component of NADPH oxidase in gastroduodenal diseases in Japan.

OBJECTIVE Superoxide has been implicated in the pathogenesis of Helicobacter pylori-related diseases through inflammation. NADPH oxidase, a major source of superoxide generation, plays a critical role in H. pylori-related gastric inflammation. The aim of this study was to clarify the effect of the p22PHOX C242T polymorphism, an essential component of NADPH… CONTINUE READING