Association of polymorphism of estrogen receptor-alpha gene with circulating levels of adiponectin in postmenopausal women with type 2 diabetes.

@article{Yoshihara2009AssociationOP,
  title={Association of polymorphism of estrogen receptor-alpha gene with circulating levels of adiponectin in postmenopausal women with type 2 diabetes.},
  author={Rie Yoshihara and Kazunori Utsunomiya and Atsushi Gojo and Sho Ishizawa and Yasushi Kanazawa and Keiichiro Matoba and Kanta Taniguchi and Tamotsu Yokota and Hideaki Kurata and Jun-Ichi Yokoyama and Mitsuyoshi Urashima and Naoko Tajima},
  journal={Journal of atherosclerosis and thrombosis},
  year={2009},
  volume={16 3},
  pages={250-5}
}
AIM Menopause is a risk factor for cardiovascular disease (CVD) in women because of the reduction in endogenous estrogen. Recently, single nucleotide polymorphisms (SNPs) of the estrogen receptor alpha (ESR-1) gene (c.454-397T>C) associated with the prognosis of myocardial infarction in postmenopausal women were identified; however, the mechanism by which genetic variation of ESR-1 contributes to the pathogenesis of CVD is unknown. Circulating levels of adipokines and inflammatory cytokines… CONTINUE READING

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Type II diabetes mellitus and menopause: a multinational study.

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