Association of polymorphic alleles of the calcium-sensing receptor gene with the clinical severity of primary hyperparathyroidism.

@article{Yamauchi2001AssociationOP,
  title={Association of polymorphic alleles of the calcium-sensing receptor gene with the clinical severity of primary hyperparathyroidism.},
  author={Mika Yamauchi and Tamotsu Sugimoto and Toru Yamaguchi and Shozo Yano and Maki Kanzawa and Akira Kobayashi and Kazuo Chihara},
  journal={Clinical endocrinology},
  year={2001},
  volume={55 3},
  pages={373-9}
}
OBJECTIVE Primary hyperparathyroidism (pHPT) is a heterogeneous disease in its clinical course and severity. Previous studies have suggested an association between the clinical severity of pHPT and the genotypes of vitamin D receptor, oestrogen receptors and PTH molecules. The Ca-sensing receptor (CaR) is activated by an extracellular calcium ion and controls PTH secretion, and thus polymorphisms of CaR might be associated with the magnitude of PTH secretion and the clinical severity of pHPT… CONTINUE READING

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