Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese.

@article{Machida2005AssociationOP,
  title={Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese.},
  author={Haruhisa Machida and Kazuhiro Tsukamoto and Chun-Yang Wen and Yukiko Narumi and Saburou Shikuwa and Hajime Isomoto and Fuminao Takeshima and Yohei Mizuta and Norio Niikawa and Ikuo Murata and Shigeru Kohno},
  journal={World journal of gastroenterology},
  year={2005},
  volume={11 27},
  pages={4188-93}
}
AIM To examine an association between the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene that plays a role in downregulation of T-cell activation and inflammatory bowel disease consisting of ulcerative colitis (UC) and Crohn's disease (CD) in the Japanese. METHODS We studied 108 patients with UC, 79 patients with CD, and 200 sex-matched healthy controls, with respect to three single nucleotide polymorphisms (SNPs) in CTLA4, such as C-318T in the promoter region, A+49G in exon 1 and G+6230A in… CONTINUE READING

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