Association of poly(A) mRNA with microtubules in cultured neurons.

@article{Bassell1994AssociationOP,
  title={Association of poly(A) mRNA with microtubules in cultured neurons.},
  author={Gary Jonathan Bassell and Robert H Singer and Kenneth S. Kosik},
  journal={Neuron},
  year={1994},
  volume={12 3},
  pages={571-82}
}
The structural basis for the synthesis of specific proteins within distinct intraneuronal compartments is unknown. We studied the distribution of poly(A) mRNA within cultured cerebrocortical neurons using high resolution in situ hybridization to identify cytoskeletal components that may anchor mRNA. After 1 day in culture, poly(A) mRNA was distributed throughout all of the initial neurites, including the axon-like process. At 4 days in culture, poly(A) mRNA was distributed throughout the cell… CONTINUE READING

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