Association of plasma lipids and apolipoproteins with the insulin response element in the apoC-III promoter region in familial combined hyperlipidemia.

@article{Groenendijk1999AssociationOP,
  title={Association of plasma lipids and apolipoproteins with the insulin response element in the apoC-III promoter region in familial combined hyperlipidemia.},
  author={Martine Groenendijk and Rita M. Cantor and Nikolaj Blom and Jerome I. Rotter and Tjerk W. A. de Bruin and Geesje M. Dallinga-Thie},
  journal={Journal of lipid research},
  year={1999},
  volume={40 6},
  pages={1036-44}
}
The apoAI-CIII-AIV gene cluster, located on chromosome 11, contributes to the phenotype of familial combined hyperlipidemia (FCH), but this contribution is genetically complex. Combinations of haplotypes, based on three restriction enzyme polymorphisms: XmnI and MspI sites, 5' of the start site of the apoA-I gene and SstI polymorphism in the 3' untranslated region of exon 4 of the apoC-III gene, were analyzed to characterize their effect on the expression of severe hyperlipidemia. An epistatic… CONTINUE READING
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The high risk combination of haplotypes in the apo AI-CIII-AIV gene cluster: further exploration of the epistasis. Circulation

G. M. Dallinga-Thie, M. Groenendijk, N.H.H.C. Blom, T.W.A. de Bruin
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