Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.

@article{Antoniades2009AssociationOP,
  title={Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.},
  author={Charalambos Antoniades and Cheerag Shirodaria and Paul Leeson and Alexios S Antonopoulos and Nicholas Warrick and Tim Van-Assche and C. Willett Cunnington and Dimitris Tousoulis and Ravi C Pillai and Chandi Ratnatunga and Christodoulos Stefanadis and Keith M. Channon},
  journal={European heart journal},
  year={2009},
  volume={30 9},
  pages={1142-50}
}
BACKGROUND Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), is considered to be a risk factor for atherosclerosis. However, the mechanisms relating ADMA with vascular function have been evaluated in vitro and in animal models, but its effect in human vasculature is unclear. AIMS We examined the impact of serum ADMA on endothelial nitric oxide (NO) bioavailability and vascular superoxide radical (O2-) production in patients with… CONTINUE READING

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