Association of phosphatidylinositol 3 kinase to protein kinase C zeta during interleukin-2 stimulation.

@article{Gomez1996AssociationOP,
  title={Association of phosphatidylinositol 3 kinase to protein kinase C zeta during interleukin-2 stimulation.},
  author={Josefa Gomez and Carlos Mart{\'i}nez and Angela Garcia and A. Barrera Rebollo},
  journal={European journal of immunology},
  year={1996},
  volume={26 8},
  pages={
          1781-7
        }
}
Interleukin-2 induces a serine-phosphorylated phosphatidylinositol 3 kinase activity in the mouse T cell line TS1 alpha beta. Moreover, protein kinase C (PKC) zeta directly or indirectly associates with the phosphatidylinositol 3 kinase and the association appears to be necessary for the serine-phosphorylated phosphatidylinositol 3 kinase activity, since release of zeta PKC by competition of binding with peptides spanning the p110 sequence from amino acids 907 to 925 abolishes the serine… CONTINUE READING

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