Association of pRas and pRaf-1 in a complex correlates with activation of a signal transduction pathway.

@article{Finney1993AssociationOP,
  title={Association of pRas and pRaf-1 in a complex correlates with activation of a signal transduction pathway.},
  author={R E Finney and Stephen M. Robbins and J. Michael Bishop},
  journal={Current biology : CB},
  year={1993},
  volume={3 12},
  pages={805-12}
}
BACKGROUND A key pathway for transduction of proliferative, developmental and oncogenic stimuli from receptors at the cell surface to transcription factors located in the nucleus involves the activation of pRas and pRaf-1. Recent publications have described a physical interaction between pRas and pRaf-1, either as ectopic proteins in yeast or as recombinant proteins added to cellular extracts. Until now, however, physical complexes that include pRas and pRaf-1 have not been identified as native… CONTINUE READING