Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials.

@article{Hacke2004AssociationOO,
  title={Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials.},
  author={Werner Hacke and Geoffrey Donnan and Cesare Fieschi and M Kaste and R{\"u}diger von Kummer and J P Broderick and Thomas Brott and Michael Frankel and James C. Grotta and E. Clarke Jr Haley and Thomas M Kwiatkowski and Steven Richard Levine and Chris A Lewandowski and M. Z. Lu and Patrick D. Lyden and John R. Marler and Suresh Patel and Barbara Claire Tilley and Gregory C Albers and Erich Bluhmki and Manfred Gerald Wilhelm and Scott J Hamilton},
  journal={Lancet},
  year={2004},
  volume={363 9411},
  pages={
          768-74
        }
}
BACKGROUND Quick administration of intravenous recombinant tissue plasminogen activator (rt-PA) after stroke improved outcomes in previous trials. We aimed to analyse combined data for individual patients to confirm the importance of rapid treatment. METHODS We pooled common data elements from six randomised placebo-controlled trials of intravenous rt-PA. Using multivariable logistic regression we assessed the relation of the interval from stroke onset to start of treatment (OTT) on… CONTINUE READING
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