Association of obesity and insulin resistance with dyslipidemia in Indian women with polycystic ovarian syndrome.
@article{Kalra2006AssociationOO, title={Association of obesity and insulin resistance with dyslipidemia in Indian women with polycystic ovarian syndrome.}, author={Anuradha Kalra and Sreekumaran Nair and Lavanya Rai}, journal={Indian journal of medical sciences}, year={2006}, volume={60 11}, pages={ 447-53 } }
BACKGROUND
Dyslipidemia, diabetes and obesity are all potent cardiovascular risk factors that tend to cluster in women with polycystic ovary syndrome (PCOS). Metabolic disorders in patients with PCOS cannot be explained solely by the presence of obesity.
OBJECTIVE
To study the correlation between insulin resistance and serum lipid profile in Indian women with PCOS.
SETTING
Gynecology clinic of a tertiary care hospital.
MATERIALS AND METHODS
In this prospective study done from April 2004…
76 Citations
Study of Insulin Resistance and Lipid Profile in Polycystic Ovarian Syndrome
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It is suggested that insulin resistance in PCOS women is associated with dyslipidemia and if measurement of insulin resistance and serum lipid profile is done early, the disease progression can be prevented and prevent future complications.
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Indian women with PCOS are at increased risk of IGT and NIDDM, and PCOS women have significant alteration in lipid profile and hence are more prone for cardiovascular disease.
EVALUATE RELATIONSHIP BETWEEN INSULIN RESISTANCE AND SERUM LIPOPROTEIN RATIO IN POLYCYSTIC OVARIAN SYNDROME
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Insulin resistance was significantly positively correlated with serum lipid profile and serum lipoprotein ratio except with serum HDL, which was significantly negatively correlated.
Association of triglycerides/high density lipoprotein cholesterol ratio with insulin resistance in polycystic ovary syndrome
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Results of present study support that TG/HDL-C ratio may be a simple indicator of IR in PCOS patients which helps clinicians to identify IR in small centers, where the assays for insulin measurement are not available.
Insulin resistance and its relation to inflammatory status and serum lipids among young women with PCOS
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IR is the hallmark of PCOS among young adolescent women and is associated with elevated CRP and triglyceride levels, which indicates that taking measures to increase insulin sensitivity, may help in altering dyslipidemia and inflammatory status, thereby reducing CVD risk among young women with PCOS.
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The prevalence of IR in PCOS Egyptian women is about 46%, BMI was significantly high in IR compared to non-IR PCOS women and the hirsutism was significantly more common inIR compared toNon-IRPCOS women.
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Reducing body mass index and waist circumference may improve insulin resistance in infertile women with polycystic ovary syndrome and subsequent counseling is recommended to address the long-term risks of metabolic syndrome.
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Anthropometric characteristics (especially BMI and hip circum-ference) are more important parameters correlated to lipid profile than IR in overweight or obese PCOS patients, confirming the importance of early treat-ment of obesity to prevent dyslipidemia in the future.
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Clinically, the G/I ratio may be beneficial in identifying insulin-resistant PCOS women and choosing those most likely to benefit from therapy interventions that increase insulin sensitivity.
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