Association of nonsyndromic Wilms tumor with premature centromere division (PCD).

Abstract

Wilms tumor was discovered in a 22-month-old otherwise healthy girl. Her pretreatment karyotype proved to be normal 46,XX with total premature division (PCD) in 21% of her lymphocyte mitoses. This phenomenon was not seen in the parents. PCD was found in less than 4% of lymphocyte mitoses of five other children with Wilms tumor. The individual finding provides further evidence for a relation of PCD to tumorigenesis; however, elucidation of the question needs further systematic studies.

Cite this paper

@article{Mhes2002AssociationON, title={Association of nonsyndromic Wilms tumor with premature centromere division (PCD).}, author={K{\'a}roly M{\'e}hes and P{\'a}l G Kajt{\'a}r and G Y Kosztol{\'a}nyi}, journal={American journal of medical genetics}, year={2002}, volume={112 2}, pages={215-6} }