Association of neuronal nitric oxide synthase C276T polymorphism with Alzheimer’s disease


Sirs: Recent evidence demonstrates that production of nitric oxide (NO) in Alzheimer’s disease (AD) is upregulated by neuronal nitric oxide synthase (nNOS) activation in reactive astrocytes surrounding β amyloid plaques present at places of clear neuronal loss [7]. In addition aberrant expression of nNOS in cortical pyramidal cells of AD brain has been… (More)
DOI: 10.1007/s00415-005-0783-2


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