Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma.

@article{Chen2006AssociationOM,
  title={Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma.},
  author={Yu-Jen Chen and Vicky Hakin-Smith and Mario Teo and George E Xinarianos and David A Jellinek and Thomas Carroll and David McDowell and Martin R Macfarlane and Ronald Boet and B. C. Baguley and Antony W. Braithwaite and Roger R Reddel and J A Royds},
  journal={Cancer research},
  year={2006},
  volume={66 13},
  pages={6473-6}
}
The molecular basis for alternative lengthening of telomeres (ALT), a prognostic marker for glioma patients, remains unknown. We examined TP53 status in relation to telomere maintenance mechanism (TMM) in 108 patients with glioblastoma multiforme and two patients with anaplastic astrocytoma from New Zealand and United Kingdom. Tumor samples were analyzed with respect to telomerase activity, telomere length, and ALT-associated promyelocytic leukemia nuclear bodies to determine their TMM. TP53… CONTINUE READING

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