Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.

@article{Zhou1987AssociationOM,
  title={Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.},
  author={D J Zhou and Hector A Battifora and Jun Yokota and Tatsuo Yamamoto and Martin J. Cline},
  journal={Cancer research},
  year={1987},
  volume={47 22},
  pages={6123-5}
}
Amplification of c-erbB-2 was at least three times more frequent in breast cancer than in most other types of carcinoma, and was not found in sarcomas or hematological malignancies. Amplification of c-erbB-2 was found in 15 of 86 primary breast cancers and in 3 of 12 secondary breast cancers. Amplification was more common in breast tumors of advanced stage, and in tumors which had metastasized to regional lymph nodes sites. Gene amplification was observed in 21% (4 of 19) of primary tumors… CONTINUE READING

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References

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Showing 1-10 of 22 references

Amplification of the c-erbB-2 oncogene in human adenocarcinomas in vivo

  • J. Yokota, M. Terada, +4 authors M. J. Cline
  • Lancet
  • 1986
Highly Influential
8 Excerpts

Amplification of a novel vI'rhll related gene in a human mammary carcinoma

  • C. R. King, M. H. Kraus, A Aaronson.S.
  • Science (Wash. DC),
  • 1985
Highly Influential
4 Excerpts

The neu oncogene: an erft-B-related gene encoding a 185,000-A/, tumor antigen

  • A. L. Schlechter, D. F. Stern, L. Vaidyanathan, el al
  • Nature (Lond.),
  • 1984
Highly Influential
4 Excerpts

Overexpression of the human c - erbB2 oncoprotein in human breast carcinomas : immunohistochemical as sessment correlates with gene amplification

  • D. J. Venter, S. Kumar, N. L. Tuzi
  • Lancet
  • 1987

Overexpression of the human cerbB-2 oncoprotein in human breast carcinomas: immunohistochemical as sessment correlates with gene

  • D. J. Venter, S. Kumar, N. L. Tuzi
  • amplification. Lancet,
  • 1987

An ere-A-related gene, c-erbB2, encodes a possible receptor protein similar to the epidermoid growth factor receptor

  • T. Yamamoto, S. Ikawa, T Akiyama
  • Nature (Lond.)
  • 1986
2 Excerpts

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