Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population.

@article{Nishizawa2006AssociationOM,
  title={Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population.},
  author={Daisuke Nishizawa and Wenhua Han and Junko Hasegawa and Takafumi Ishida and Yukio Numata and Tadahiro Sato and Atsuko Kawai and Kazutaka Ikeda},
  journal={Neuropsychobiology},
  year={2006},
  volume={53 3},
  pages={137-41}
}
Ethanol is considered to activate the brain reward system by increasing the release of an endogenous opioid receptor ligand, beta-endorphin. The polymorphism A118G in the mu-opioid receptor gene (OPRM1) causes the amino acid change Asn40Asp and has been reported to affect the affinity of the ligand for the receptor. The association of this polymorphism with the vulnerability to alcohol dependence has been studied in many populations, but not yet in Japanese people. In the present study, we… CONTINUE READING
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