Association of monoamine oxidase A (MAOA) polymorphisms and clinical subgroups of major depressive disorders in the Han Chinese population

@article{Huang2009AssociationOM,
  title={Association of monoamine oxidase A (MAOA) polymorphisms and clinical subgroups of major depressive disorders in the Han Chinese population},
  author={San-Yuan Huang and Ming-Teng Lin and Wei-Wen Lin and Cheng-Chang Huang and Mee-Jen Shy and Ru-Band Lu},
  journal={The World Journal of Biological Psychiatry},
  year={2009},
  volume={10},
  pages={544 - 551}
}
It has been proposed that an MAOA abnormality may be an important factor in the development of major depressive disorder (MDD). Various polymorphisms of the MAOA gene have been investigated for possible associations with mood disorders, but results have been inconsistent. The goal of the present study was to investigate whether polymorphisms of the MAOA gene are associated with MDD or alternatively with different clinical subgroups of MDD. A total of 590 Han Chinese subjects in Taiwan (312… 

Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population

This study suggests that the interaction between genetic variants within the MAOA gene may contribute to an increased risk of paranoid schizophrenia, but the precise mechanism needs further investigation.

Association study between monoamine oxidase A (MAOA) gene polymorphisms and schizophrenia: lack of association with schizophrenia and possible association with affective disturbances of schizophrenia

The results suggest that exonic SNPs of the MAOA gene may be contributed to affective disturbances of Korean males schizophrenia, especially restricted affect and blunted affect.

MAOA Variants and Genetic Susceptibility to Major Psychiatric Disorders

It is confirmed that MAOA is a risk gene for psychiatric disorders, and the results provide useful information toward a better understanding of genetic mechanism involving MAOA underlying risk of complex psychiatric disorders.

Association and Interaction of the MAOA Promoter uVNTR Polymorphism with Suicide Attempts in Patients with Major Depressive Disorder

The MAOA long-form variant was associated with enhanced vulnerability to suicide in the general population and neuroticism, extraversion, low levels of anxiety, high levels of depressive symptoms, and smoking were associated with suicidal behavior in MDD group, not in the group of subjects without MDD.

Association of the MAOA promoter uVNTR polymorphism with suicide attempts in patients with major depressive disorder

The MAOA 4R allele is associated with enhanced vulnerability to suicide in depressed males, but not in community subjects, and nongenetic factors, such as age, paternal overprotection, and somatic symptoms, were associated with MDD, whereas depressed suicide wereassociated with severity of depression, personality traits, age, marital status, and inversely associated with anxiety symptoms.

Meta-analysis of the association between the monoamine oxidase-A gene and mood disorders

The systematic meta-analysis suggests a significant association of the MAOA gene with major depressive disorder and BPD within specific groups, indicating that these three polymorphisms of theMAOA gene may be associated with mood disorders by sex and ethnicity.

MAOA uVNTR Genetic Variant and Major Depressive Disorder: A Systematic Review

There is still no consensus on the MAOA uVNTR variant’s role in MDD pathogenesis, and higher 3R/3R and 3R* genotype frequencies in the healthy control groups and higher 4R/4R (female) and 4R* (male) genotypes in the MDD groups in the majority of different populations.

Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities.

Depression in females may result from a gene × childhood-adversity interaction and/or a dysregulated epigenetic programming of MAOA, and childhood- adversity subtypes may differentially impact DNA methylation at NR3C1; baseline MAOA-genotypic variations may affect the extent of NR 3C1 methylation.

Association study of the dopamine transporter gene with personality traits and major depressive disorder in the Han Chinese population

A borderline association between controls and total major depression and between major depression with family history versus controls is found and a major role for DAT1 is not confirmed in the susceptibility to major depression.

References

SHOWING 1-10 OF 38 REFERENCES

Association Study of a Monoamine Oxidase A Gene Promoter Polymorphism with Major Depressive Disorder and Antidepressant Response

The findings suggest that the MAOA-uVNTR may be involved in the pathogenesis of MDD and the antidepressant therapeutic mechanisms in Chinese population, and that there may be a gender effect in this association.

Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder.

It is suggested that an excess of high-activity MAO-A gene promoter alleles resulting in an elevated MAo-A activity is a risk factor for major depressive disorder in females.

Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disorders

The results suggest that MAOA gene variation may modulate the expression of some clinical aspects of severe mood disorders, especially in females, and support the existence of a genetic and aetiologic heterogeneity underlying the diagnoses of bipolar disorder and major depression.

Association analysis between mood disorder and monoamine oxidase gene.

To ascertain whether mood disorders, including bipolar and unipolar, are genetically associated with the monoamine oxidase A (MAOA) or monoamine oxidase B (MAOB) gene in the Chinese population, 132

Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders.

There is no association between MAOA-LPR genotype and susceptibility to recurrent major depression, bipolar disorder, and schizophrenia in the population of patients tested.

A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders

It is suggested that the functional VNTR polymorphism in the MAOA gene is unlikely to play a major role in the pathogenesis of bipolar disorder or unipolar depression, and no association between the polymorphism and a history of suicide attempt is found.

Association study of MAO-A, COMT, 5-HT2A, DRD2, and DRD4 polymorphisms with illness time course in mood disorders.

The results suggest that MAO-A, COMT, catechol-O-methyltransferase, 5-HT2A, DRD2, and DRD4 gene variants are not involved in susceptibility toward different time courses in mood disorders.

Additional evidence that genetic variation of MAO-A gene supports a gender subtype in obsessive-compulsive disorder.

The MAO-A/EcoRV polymorphism was reexamined in a sample of 122 OCD patients and 124 healthy subjects to provide molecular evidence to identify a clinically meaningful gender subtype and suggest the possibility of gender differences in genetic susceptibility for OCD.

Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder.

It is suggested that increased monoamine oxidase A activity is a risk factor for panic disorder in female patients because the longer alleles (3a, 4 and 5) were more active than allele 3.