Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.

@article{Couch2010AssociationOM,
  title={Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.},
  author={Fergus J. Couch and Xianshu Wang and William R. Bamlet and Mariza de Andrade and G. M. van Petersen and Robert R McWilliams},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2010},
  volume={19 1},
  pages={251-7}
}
BACKGROUND Mitosis is a highly regulated process that serves to ensure the fidelity of cell division. The disruption of mitotic regulators leading to aneuploidy and polyploidy is commonly observed in cancer cells. Single nucleotide polymorphisms (SNP) in regulators of mitosis may promote chromosome missegregation and influence pancreatic cancer and/or survival. METHODS Thirty-four SNPs, previously associated with breast cancer risk, from 33 genes involved in the regulation of mitosis, were… CONTINUE READING
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