Association of mitogen-activated protein kinase with the microtubule cytoskeleton.

  title={Association of mitogen-activated protein kinase with the microtubule cytoskeleton.},
  author={Alfred A. Reszka and Rony Seger and Chris Diltz and Edwin G. Krebs and Edmond Henri Fischer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={92 19},
Using indirect immunofluorescence microscopy and biochemical techniques, we have determined that approximately one-third of the total mitogen-activated protein kinase (MAPK) is associated with the microtubule cytoskeleton in NIH 3T3 mouse fibroblasts. This population of enzyme can be separated from the soluble form that is found distributed throughout the cytosol and is also present in the nucleus after mitogen stimulation. The microtubule-associated enzyme pool constitutes half of all… CONTINUE READING

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