Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from Africa.

@article{Andriantsoanirina2010AssociationOM,
  title={Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from Africa.},
  author={Val{\'e}rie Andriantsoanirina and Didier M{\'e}nard and St{\'e}phane Rabearimanana and V{\'e}ronique Hubert and Christiane Bouchier and Magali Tichit and Jacques Le Bras and R{\'e}my Durand},
  journal={The American journal of tropical medicine and hygiene},
  year={2010},
  volume={82 5},
  pages={782-7}
}
We sought to test the association of polymorphisms in Plasmodium falciparum nhe-1 (Pfnhe-1, gene PF13_0019) with in vitro susceptibility to quinine, which was previously reported in a limited number of reference strains or culture-adapted isolates. Determination of in vitro susceptibility to quinine, genotyping of Pfnhe-1 ms4760 microsatellite and polymorphism in codon 76 of Pfcrt were performed for 83 isolates obtained from symptomatic malaria-infected travelers returning from various African… CONTINUE READING