Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients.

@article{Mrissa2013AssociationOM,
  title={Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients.},
  author={Najiba Fekih Mrissa and Meriem Mrad and Sarra Klai and Jamel Zaouali and Aycha Sayeh and Chakib Mazigh and Brahim Nsiri and Salem Machgoul and Nasreddine Gritli and Ridha Mrissa},
  journal={Clinical neurology and neurosurgery},
  year={2013},
  volume={115 9},
  pages={1657-60}
}
BACKGROUND AND OBJECTIVE Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination of nerve axons. The aim of this study was to investigate a possible association between the methylenetetrahydrofolate reductase (MTHFR) gene and multiple sclerosis in Tunisian patients. PATIENTS AND METHODS The genotyping of two missense variants of the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C was performed in… CONTINUE READING
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