Association of methacholine challenge test with diagnosis of chronic lung allograft dysfunction in lung transplant patients

@article{Siddiqui2018AssociationOM,
  title={Association of methacholine challenge test with diagnosis of chronic lung allograft dysfunction in lung transplant patients},
  author={Atif S Siddiqui and G. Kumar and T. Majumdar and E. Graviss and D. Nguyen and A. Goodarzi and T. Kaleekal},
  journal={Clinical Transplantation},
  year={2018},
  volume={32}
}
Chronic lung allograft dysfunction (CLAD) is a complication of lung transplantation. We sought to determine whether bronchial hyperresponsiveness detected by the methacholine challenge test (MCT) at 3 months after lung transplant (LT) predicts the development of CLAD. 
Noninvasive methods for detection of chronic lung allograft dysfunction in lung transplantation.
Lung transplantation (LTx) is the only therapeutic option for end-stage lung diseases. Chronic lung allograft dysfunction (CLAD), which manifests as airflow restriction and/or obstruction, is theExpand
Early Identification of Chronic Lung Allograft Dysfunction: The Need of Biomarkers
TLDR
Significant studies are described that have highlighted potential candidates for reliable and non-invasive biomarkers of CLAD in the fields of imaging and functional monitoring, humoral immunity, cell-mediated immunity, allograft injury, airway remodeling and gene expression that would improve CLAD prediction and allow differential LT management regarding CLAD risk. Expand

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