Association of metabolic–bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants

  title={Association of metabolic–bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants},
  author={Nicholas Lx Syn and David E. Cummings and Louis Zizhao Wang and Daryl Jimian Lin and Joseph J. Zhao and Marie Loh and Zong Jie Koh and Claire Alexandra Zhen Chew and Ying Ern Loo and Bee Choo Tai and Guowei Kim and Jimmy Bok-Yan So and Lee M. Kaplan and John B. Dixon and Asim Shabbir},
  journal={The Lancet},

Long-Term Cardiovascular Outcomes After Bariatric Surgery in the Medicare Population.

Effect of Bariatric Surgery on Survival and Hospitalizations in Patients with Severe Obesity. A Retrospective Cohort Study

BS significantly reduced the risk of all-cause mortality and hospitalization after 10-year follow-up and when comparing hospitalization risk in the BS group only, a marked reduction after surgery was found for all BS types.

Long-term Effect of Lifestyle Interventions on the Cardiovascular and All-Cause Mortality of Subjects With Prediabetes and Type 2 Diabetes: A Systematic Review and Meta-analysis.

Intensive lifestyle interventions implemented so far did not show superiority to usual care in reducing cardiovascular or all-cause mortality for subjects with prediabetes and type 2 diabetes.

Cost-Effectiveness of Bariatric Surgery in Tunisia

From the Tunisian healthcare payor perspective, bariatric surgery is cost-effective for patients with obesity and those with type 2 diabetes mellitus and obesity-related comorbidities.

Seven-year trajectories of body weight, quality of life and comorbidities following Roux-en-Y gastric bypass and sleeve gastrectomy

Both SG and RYGB are safe procedures with significant long-term weight-loss, improvement of QOL and amelioration of comorbidities and remain below reference data from the general population at all timepoints.

The effects of laparoscopic Roux-en-Y gastric bypass and one-anastomosis gastric bypass on glycemic control and remission of type 2 diabetes mellitus: study protocol for a multi-center randomized controlled trial (the DIABAR-trial)

The DIABAR-trial is one of the few randomized controlled trials primarily aimed to evaluate the glycemic response after the RYGB and OAGB in severe obese patients diagnosed with T2DM.

Effects of Colchicine on Cardiovascular Outcomes in Patients with Coronary Artery Disease: A Systematic Review and One-Stage and Two-Stage Meta-Analysis of Randomized-Controlled Trials

It is proposed that colchicine may be considered as an additional pharmacological adjunct to the first line therapy for patients with coronary artery disease.

Long-term outcomes of laparoscopic sleeve gastrectomy in those with class I obesity: safety, efficacy, and quality of life.

The future of bariatric surgery research: A worldwide mapping of registered trials

A systematic review of RCTs evaluating BS versus another surgical procedure or versus a medical control group, through a search in found the most frequent outcomes to be investigated are obesity‐related diseases with the study of type 2 diabetes, followed by weight loss, quality of life, and surgical complications.

A multi-center study on glucometabolic response to bariatric surgery for different subtypes of obesity

In terms of glucometabolism, the four AIM subtypes of patients benefited differently from a bariatric surgery, which significantly relieved hyperglycemia and hyperinsulinemia for the LMO and HMO-I patients, respectively.

Association between bariatric surgery and long-term survival.

Those who underwent bariatric surgery compared with matched control patients who did not have surgery had lower all-cause mortality at 5 years and up to 10 years following the procedure, providing further evidence for the beneficial relationship between surgery and survival that has been demonstrated in younger, predominantly female populations.

Bariatric Surgery and Long-term Survival in Patients With Obesity and End-stage Kidney Disease.

Among patients with obesity and end-stage kidney disease, bariatric surgery was associated with lower all-cause mortality compared with usual care and an increase in kidney transplant.

Association Between Bariatric Surgery and All-Cause Mortality: A Population-Based Matched Cohort Study in a Universal Health Care System

Bariatric surgery was associated with substantially lower all-cause, cardiovascular, and cancer mortality and the lowered observed mortality of surgery was significant across most subgroups.

A 23-year study of mortality and development of co-morbidities in patients with obesity undergoing bariatric surgery (laparoscopic gastric banding) in comparison with medical treatment of obesity

The preventive effect of LAGB on mortality is maintained up to 23 years, even with a decreased efficacy compared with the shorter-time study, while the preventive effect on co-morbidities and on hospital admissions increases with time.

Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials

Compared with non-surgical treatment of obesity, bariatric surgery leads to greater body weight loss and higher remission rates of type 2 diabetes and metabolic syndrome and greater improvements in quality of life and reductions in medicine use.

Bariatric surgery, compared to medical treatment, reduces morbidity at all ages but does not reduce mortality in patients aged < 43 years, especially if diabetes mellitus is present: a post hoc analysis of two retrospective cohort studies

The findings raise the question whether morbid obese patients should undergo BS as soon as possible, or whether patients might undergo surgery later in their life, as a result of the effect of aging.

Surgery Decreases Long-term Mortality, Morbidity, and Health Care Use in Morbidly Obese Patients

This study shows that weight-loss surgery significantly decreases overall mortality as well as the development of new health-related conditions in morbidly obese patients.

Association of Bariatric Surgery Using Laparoscopic Banding, Roux-en-Y Gastric Bypass, or Laparoscopic Sleeve Gastrectomy vs Usual Care Obesity Management With All-Cause Mortality

Among obese patients in a large integrated health fund in Israel, bariatric surgery using laparoscopic banding, gastric bypass, or Laparoscopic sleeve gastrectomy, compared with usual care nonsurgical obesity management, was associated with lower all-cause mortality over a median follow-up of approximately 4.5 years.

Potential Benefits and Harms of Gastric Bypass Surgery in Obese Individuals With Type 1 Diabetes: A Nationwide, Matched, Observational Cohort Study

This observational study suggests bariatric surgery may yield similar benefits on risk for cardiovascular outcomes and mortality in patients with T1D and obesity as for patients with type 2 diabetes, however, some potential serious adverse effects suggest need for careful monitoring of such patients after surgery.