Association of megalin genetic polymorphisms with prostate cancer risk and prognosis.

  title={Association of megalin genetic polymorphisms with prostate cancer risk and prognosis.},
  author={Sarah K. Holt and Danielle M. Karyadi and Erika M. Kwon and Janet L. Stanford and Peter S. Nelson and Elaine A Ostrander},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={14 12},
PURPOSE Megalin, an endocytic receptor expressed by prostate epithelial cells, can internalize biologically active androgens bound to sex hormone binding globulin. Genetic variation within megalin could potentially influence levels of steroid hormone uptake. EXPERIMENTAL DESIGN Forty haplotype-tagging single-nucleotide polymorphisms (htSNP) were analyzed in a population-based, case-control study of 553 Caucasian men who were diagnosed with prostate cancer between the ages of 40 and 64 years… CONTINUE READING


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