Association of matrix metalloproteinases 1, 7, and 9 gene polymorphisms with genetic susceptibility to colorectal carcinoma in a Han Chinese population.

@article{Fang2010AssociationOM,
  title={Association of matrix metalloproteinases 1, 7, and 9 gene polymorphisms with genetic susceptibility to colorectal carcinoma in a Han Chinese population.},
  author={Wen-liang Fang and Wei-bo Liang and H. David He and Yi Zhu and Shi-Liu Li and Lin-bo Gao and Lin Zhang},
  journal={DNA and cell biology},
  year={2010},
  volume={29 11},
  pages={657-61}
}
Matrix metalloproteinases (MMPs) play an important role in colorectal cancer (CRC). Accumulated evidence suggests an association between MMP-1, MMP-7, and MMP-9 functional gene polymorphisms with several tumors. The aim of this study was to investigate the association of single-nucleotide polymorphism (SNP) at MMP-1 16071G/2G, MMP-7 181A/G, and MMP-9 279R/Q genes with CRC in the southwest Chinese Han population. The study used 237 CRC patients and 252 normal control matched by age and sex from… CONTINUE READING

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