Association of matrix metalloproteinases (MMP2, MMP7 and MMP9) genetic variants with left ventricular dysfunction in coronary artery disease patients.

@article{Mishra2012AssociationOM,
  title={Association of matrix metalloproteinases (MMP2, MMP7 and MMP9) genetic variants with left ventricular dysfunction in coronary artery disease patients.},
  author={Avshesh Mishra and Anshika Srivastava and Tulika Mittal and Naveen Garg and Balraj Mittal},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2012},
  volume={413 19-20},
  pages={
          1668-74
        }
}
Emerging Role of Genetic Variants of Matrix Metalloproteinases Genes in Left Ventricular Dysfunction
TLDR
The study concludes that MMP9 R668Q polymorphism plays significant role in conferring genetic susceptibility to left ventricular dysfunction in coronary artery disease patients.
The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): a systematic review and meta-analysis
TLDR
The meta-analysis revealed that MMP-9 (C1562T) SNP conferred a susceptibility risk for CAD in the overall analysis and Asian population, and theOverall analysis and subgroup analysis of the other three SNPs reject the association between M MP-9 polymorphisms and the risk of CAD.
Role of common sarcomeric gene polymorphisms in genetic susceptibility to left ventricular dysfunction
TLDR
The results showed that MYBPC3 25-bp deletion polymorphism was significantly associated with elevated risk of LVD (LVEF <45) and other parameters of LV remodelling, i.e. LV dimensions (LV end diastole dimension,LVEDD: P = 0.037 and LV end systolic dimension, LVESD: 0.032).
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References

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Association of 25 bp Deletion in MYBPC3 Gene with Left Ventricle Dysfunction in Coronary Artery Disease Patients
TLDR
The frequency of MYBPC3 DW genotype and D allele was associated with compromised LVEF implying that genetic variants of myosin binding protein C encoding mutant structural sarcomere protein could increase susceptibility to left ventricular dysfunction.
Impact of Renin-Angiotensin-Aldosterone System Gene Polymorphisms on Left Ventricular Dysfunction in Coronary Artery Disease Patients
TLDR
AT1 A1166C plays important role in conferring susceptibility of LVD through association of single nucleotide polymorphisms in angiotensin I converting enzyme and aldosterone synthase with LVD.
Functional polymorphisms of matrix metallopeptidase-9 and risk of coronary artery disease in a Chinese population
TLDR
It is suggested that MMP-9 R279Q, P574R and R668Q may have combined effect in the occurrence of CAD and −1562 CT/TT genotypes may contribute to CAD in diabetics and MI in CAD patients.
Matrix metalloproteinase 9 polymorphism and outcome after myocardial infarction
TLDR
The results indicate that the polymorphism does not seem to be associated with clinical outcome and in particular with the development of left ventricular dysfunction and heart failure.
Plasma tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9: novel indicators of left ventricular remodelling and prognosis after acute myocardial infarction.
TLDR
TIMP-1 and MMP-9 correlate with echocardiographic parameters of LV dysfunction and remodelling after AMI and may identify patients at risk of subsequent LV remodelling and adverse prognosis.
A Matrix Metalloproteinase Induction/Activation System Exists in the Human Left Ventricular Myocardium and Is Upregulated in Heart Failure
TLDR
Increased LV myocardial MMP activity and selective upregulation of MMPs with nonischemic and ischemic forms of DCM occurred and a local MMP induction/activation system was identified in isolated normal human LV myocytes that was upregulated with DCM.
Haplotype Analysis of the Stromelysin‐1 (MMP3) and Gelatinase B (MMP9) Genes in Relation to Coronary Heart Disease
TLDR
Common genetic variations in the MMP3 gene may affect the risk of CHD in the Chinese population, and haplotype analysis identified both the 6A‐C‐Lys (‐1612 6A, ‐376C, 45Lys) haplotype and the6A‐G‐LYS (‐1562C/T and R279Q) haplotypes of MMP9 as associated with an increased risk ofCHD.
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