Association of maternal prenatal acetaminophen use with the risk of attention deficit/hyperactivity disorder in offspring: A meta-analysis

@article{Gou2019AssociationOM,
  title={Association of maternal prenatal acetaminophen use with the risk of attention deficit/hyperactivity disorder in offspring: A meta-analysis},
  author={Xiaoyun Gou and Yan Wang and Ying Tang and Yi Qu and Jun Tang and Jing Shi and Dongqiong Xiao and Dezhi Mu},
  journal={Australian \& New Zealand Journal of Psychiatry},
  year={2019},
  volume={53},
  pages={195 - 206}
}
Background: Acetaminophen is a widely used medication for fever and pain management during pregnancy. However, recent studies have found a possible connection between maternal prenatal acetaminophen use and attention deficit/hyperactivity disorder in children. Objective: We aimed to explore the association between maternal acetaminophen use during pregnancy and the risk of attention deficit/hyperactivity disorder in offspring. Data sources: PubMed, Embase, Web of Science and Cochrane Library… 
Association of Prenatal Acetaminophen Exposure Measured in Meconium With Risk of Attention-Deficit/Hyperactivity Disorder Mediated by Frontoparietal Network Brain Connectivity.
TLDR
Causal mediation analysis was used to test for mediation of the association between prenatal acetaminophen exposure and hyperactivity by resting-state brain connectivity, and this work suggests caution should be used in administeringacetaminophen during pregnancy.
Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts
TLDR
Prenatal exposure to acetaminophen was associated with ASC or ADHD symptoms and boys and girls showed higher odds for ASC and ADHD symptoms after prenatal exposure, though these associations were slightly stronger among boys.
Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood.
TLDR
Cord biomarkers of fetal exposure to acetaminophen were associated with significantly increased risk of childhood ADHD and ASD in a dose-response fashion and support previous studies regarding the association between prenatal and perinatal acetaminphen exposure and childhood neurodevelopmental risk.
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TLDR
Exposure to acetaminophen during pregnancy appears to not increase the risk of the outcomes analyzed, and there is a lack of information regarding the exposure dose and frequency ofacetaminophen use.
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TLDR
The findings provide some clues, but additional investigation into oxidative stress pathways and the association of acetaminophen exposure and childhood ADHD is warranted.
Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis
TLDR
Additional evidence supported the association between fever during pregnancy and increased risk for NDD in offspring and careful monitoring should be considered for children born from mothers with a febrile episode during pregnancy.
Invited Commentary: The Disillusionment of Developmental Origins of Health and Disease (DOHaD) Epidemiology
TLDR
A meta-analysis of the association between in utero acetaminophen exposure and risks of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) found a 20%-30% higher risk of ADHD and ASD following prenatal acetaminphen exposure.
Over-the-counter analgesics during pregnancy: a comprehensive review of global prevalence and offspring safety.
TLDR
The evidence of foetal exposure to OTC analgesia, starting from different routes of exposure to evidence, or the lack thereof, linking maternal consumption to offspring ill health is examined.
Increased risk of preeclampsia after use of paracetamol during pregnancy – causal or coincidence?
TLDR
The use of paracetamol in the third trimester of pregnancy was associated with preeclampsia and this observation indicates that association between par acetamol use and pree clampsia is probably due to reverse causation, i.e. women with preeClampsia experience more headaches due to preeclamping symptoms since this association was not detected with the use ofParacetamols in earlier stages of pregnancy.
Paracetamol (Acetaminophen) and the Developing Brain
TLDR
The data analyzed point to a dose–effect relationship but cannot fully account for unmeasured confounders, notably indication and genetic transmission, which deserves further investigation.
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