Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage.

@article{Hiby2008AssociationOM,
  title={Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage.},
  author={Susan E. Hiby and Leslie Regan and Winne Lo and Lydia E Farrell and Mary N Carrington and Ashley Moffett},
  journal={Human reproduction},
  year={2008},
  volume={23 4},
  pages={
          972-6
        }
}
BACKGROUND The natural killer (NK) cells at the site of placentation express killer-cell immunoglobulin-like receptors (KIR) that can bind to human leukocyte antigen (HLA)-C molecules on trophoblast cells. Both these gene systems are polymorphic and an association of particular maternal KIR/fetal HLA-C genotypes has been shown in pre-eclampsia. Pre-eclampsia and recurrent miscarriage (RM) share the pathogenesis of defective placentation and therefore we have now genotyped couples with RM… CONTINUE READING
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