Association of marginal folate depletion with increased human chromosomal damage in vivo: demonstration by analysis of micronucleated erythrocytes.

@article{Everson1988AssociationOM,
  title={Association of marginal folate depletion with increased human chromosomal damage in vivo: demonstration by analysis of micronucleated erythrocytes.},
  author={Richard Everson and Carol M Wehr and Gregory L. Erexson and James T Macgregor},
  journal={Journal of the National Cancer Institute},
  year={1988},
  volume={80 7},
  pages={525-9}
}
Recent studies have demonstrated that in the absence of spleen function, frequencies of micronuclei (Howell-Jolly bodies) in peripheral blood rbcs can be used to measure in vivo cytogenetic damage. Among 20 subjects studied greater than or equal to 6 months after splenectomy, 1 had a frequency of micronucleated rbcs more than an order of magnitude higher than rates for the others. Initial data suggested that this subject was mildly folate-depleted, and a therapeutic trial with folate rapidly… CONTINUE READING
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