Association of mannose-binding lectin gene polymorphisms with antiphospholipid syndrome, cardiovascular disease and chronic damage in patients with systemic lupus erythematosus.

@article{Font2007AssociationOM,
  title={Association of mannose-binding lectin gene polymorphisms with antiphospholipid syndrome, cardiovascular disease and chronic damage in patients with systemic lupus erythematosus.},
  author={J Font and Manuel Ramos-Casals and Pilar Brito-Zer{\'o}n and Norma Nardi and Alicia Ib{\'a}{\~n}ez and Belen Prados Suarez and S. G. Navarro Jim{\'e}nez and Dolors T{\`a}ssies and {\'A}ngeles Garc{\'i}a-Criado and Emilio Ros and Juan Sent{\'i}s and J. C. Reverter and Francisco Lozano},
  journal={Rheumatology},
  year={2007},
  volume={46 1},
  pages={76-80}
}
OBJECTIVE To investigate the association of mannose-binding lectin (MBL)-deficient genotypes with cardiovascular disease in a large series of patients with systemic lupus erythematosus (SLE). METHODS A total of 114 patients diagnosed with SLE were included in the study. MBL polymorphisms were investigated by sequencing-based DNA typing of the promoter and exon 1 of the MBL2 gene. The genotypes 0/0, 0/XA and XA/XA were considered as MBL-low genotypes. RESULTS A higher prevalence of… CONTINUE READING