Association of mannose-binding lectin deficiency with acute invasive aspergillosis in immunocompromised patients.

Abstract

BACKGROUND Invasive aspergillosis is a devastating infection with attributable mortality of 40% despite antifungal therapy. In animal models of aspergillosis, deficiency of mannose-binding lectin (MBL), a pattern recognition receptor that activates complement, is a susceptibility factor. MBL deficiency occurs in 20%-30% of the population. We hypothesized… (More)
DOI: 10.1086/644619

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Cite this paper

@article{Lambourne2009AssociationOM, title={Association of mannose-binding lectin deficiency with acute invasive aspergillosis in immunocompromised patients.}, author={Jonathan R Lambourne and Dan Agranoff and Raoul Herbrecht and Peter F. Troke and A. M. Buchbinder and Fenella Willis and Val{\'e}rie Letscher-Bru and Samir Agrawal and Sarah R Doffman and Elizabeth Johnson and Peter White and Rosemary A. Barnes and George E. Griffin and Jodi. A. Lindsay and Tom Harrison}, journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America}, year={2009}, volume={49 10}, pages={1486-91} }