Association of male circumcision with risk of prostate cancer: a meta-analysis

  title={Association of male circumcision with risk of prostate cancer: a meta-analysis},
  author={N. Pabalan and E. Singian and H. Jarjanazi and A. Paganini-Hill},
  journal={Prostate Cancer and Prostatic Disease},
Background:Although early reports have suggested an association between circumcision and prostate cancer (PCa) development, results of subsequent epidemiological studies have been conflicting. Here we examine published articles that explore this association.Methods:We searched MEDLINE through PubMed and Embase for articles reporting on the association between PCa and circumcision, and performed a meta-analysis of qualifying studies.Results:On the basis of seven reports of case–control studies… Expand
10 Citations
Male circumcision and prostate cancer: A geographical analysis, meta-analysis, and cost analysis.
  • R. V. Van Howe
  • Medicine
  • Canadian Urological Association journal = Journal de l'Association des urologues du Canada
  • 2020
Circumcision may be a positive risk factor on geographical analysis, but not in case-controlled studies, and is not economically feasible for preventing prostate cancer. Expand
Male circumcision and prostate cancer: A geographical analysis, meta-analysis, and cost analysis.
Circumcision may be a positive risk factor on geographical analysis, but not in case-case-controlled studies, and is not economically feasible for preventing prostate cancer. Expand
Early infant male circumcision: Systematic review, risk-benefit analysis, and progress in policy
Affirmative MC policies are needed in Australia and New Zealand because widespread evidence from surveys, physiological measurements, and the anatomical location of penile sensory receptors responsible for sexual sensation strongly and consistently suggested that MC has no detrimental effect on sexual function, sensitivity or pleasure. Expand
Evidence for Masturbation and Prostate Cancer Risk: Do We Have a Verdict?
Findings included relations among masturbation, ejaculation frequency, and age range as individual factors of PCa risk as well as potential avenues for new research that could lead to more definitive statements about masturbation practice andPCa risk. Expand
Canadian Pediatrics Society position statement on newborn circumcision: a risk-benefit analysis revisited.
The 2015 CPS position statement on EIMC is at odds with the evidence and errors in its risk-benefit analysis are recommended, which found benefits exceed risks by approximately 100 to 1. Expand
The Ethical Course Is To Recommend Infant Male Circumcision — Arguments Disparaging American Academy of Pediatrics Affirmative Policy Do Not Withstand Scrutiny
We critically evaluate arguments in a recent Journal of Law, Medicine & Ethics article by Svoboda, Adler, and Van Howe disputing the 2012 affirmative infant male circumcision policy recommendationsExpand
CDC's Male Circumcision Recommendations Represent a Key Public Health Measure
A rebuttal to Frisch and Earp's criticisms is provided and it is argued that the recommendations are entirely appropriate and merit consideration for policy development. Expand
Identification of low oxygen-tolerating bacteria in prostate secretions of cancer patients and discussion of possible aetiological significance
The degree of significance of the substantially higher proportion of PC patients with organisms growing in a low concentration of oxygen when combined with previous studies compared to controls was as high as smoking 5–9 cigarettes a day and needs further investigation. Expand
Critical evaluation of arguments opposing male circumcision: A systematic review
To systematically evaluate evidence against male circumcision (MC), evidence is presented to support or refute the claim that circumcision is safe and effective for boys under the right circumstances. Expand


Male circumcision and penile cancer: a systematic review and meta-analysis
Men circumcised in childhood/adolescence are at substantially reduced risk of invasive penile cancer, and this effect could be mediated partly through an effect on phimosis. Expand
Circumcision reduces prostate cancer risk.
The finding of protection only in men circumcised in infancy is consistent with the well-known association of history of any sexually transmitted infections (STIs) with a 48% increase in risk of prostate cancer. Expand
Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis
The results suggest that consideration should be given to the acceptability and feasibility of providing safe services for male circumcision as an additional HIV prevention strategy in areas of Africa where men are not traditionally circumcised. Expand
Prostate cancer risk is influenced by genetic and other factors, such as a diet high in red meat (1.3-fold increase in risk) and a history sexually transmitted infections (STIs), but also syphilis, human papillomavirus, and the recently discovered Molony murine leukaemia virus homologue XMRV. Expand
Sexual factors and prostatic cancer: results from a case-control study.
The results from the study lend some support to an infectious hypothesis for prostatic cancer and the lower frequency of sexual intercourse is also noteworthy and may be indicative of a hormonal difference related to sexual interest or drive. Expand
A case-control study of cancer of the prostate in Somerset and east Devon.
This study found no association between farming and risk of prostatic cancer, nor with sexual activity as measured by number of sexual partners, and as expected with so many factors investigated, some statistically significant associations were found. Expand
Prostate cancer and sexually transmitted diseases: a meta-analysis.
Evidence is provided of a higher rate of prostate cancer in men with a history of an exposure to gonorrhea, HPV, or any STD, which is required to confirm this potentially modifiable risk factor. Expand
Sexual factors and the risk of prostate cancer.
A population-based case-control study of prostate cancer was performed in King County, Washington, in White men and Black men aged 40-64 years, and found no relation between sexual orientation and prostate cancer, although the number of men who had sex with men was small. Expand
Why circumcision is a biomedical imperative for the 21(st) century.
  • B. Morris
  • Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2007
Routine circumcision of males represents a surgical "vaccine" against a wide variety of infections, adverse medical conditions and potentially fatal diseases, and also protects their sexual partners. Expand
Medical indications for circumcision
Among boys in the former Mersey Region, 90% of Boys and appreciably fewer adult men are circumcised for three reasons; first, to reflect closely the ‘rite of passage’; second, as a prophylactic measure against future ailments (‘routine’ circumcision); and third, for some immediate medical indication. Expand