Association of major histocompatibility complex determinants with the development of symptomatic and asymptomatic genital herpes simplex virus type 2 infections.

@article{LekstromHimes1999AssociationOM,
  title={Association of major histocompatibility complex determinants with the development of symptomatic and asymptomatic genital herpes simplex virus type 2 infections.},
  author={Julie A. Lekstrom-Himes and Patricia Hohman and Terri Warren and Anna Wald and Jeong Mo Nam and Toni Simonis and Lawrence Corey and Steve E Straus},
  journal={The Journal of infectious diseases},
  year={1999},
  volume={179 5},
  pages={1077-85}
}
The clinical spectrum of herpes simplex virus (HSV) infections, ranging from asymptomatic to frequently distressing outbreaks, suggests that there may be immunologic determinants of disease severity that are associated with human leukocyte antigen (HLA) expression. A controlled, prospective study identified several major histocompatibility complex (MHC) class I and II antigens whose frequencies are associated with HSV-2 infection or with frequent symptomatic genital recurrences. Previous… CONTINUE READING
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