Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis.

@article{Smith2014AssociationOL,
  title={Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis.},
  author={Jan Gustav Smith and Kevin Ka Hang Luk and Christina-Alexandra Schulz and James C. Engert and Ron Do and George Hindy and Gull Rukh and Line Dufresne and Peter Almgren and David S Owens and Tamara B. Harris and Gina Marie Peloso and Kathleen F. Kerr and Quenna Wong and Albert Vernon Smith and Matthew J. Budoff and Jerome I. Rotter and L. Adrienne Cupples and Stephen S. Rich and Sekar Kathiresan and Marju Orho-Melander and Vilmundur Gudnason and Christopher J. O'Donnell and Wendy S. Post and George Thanassoulis},
  journal={JAMA},
  year={2014},
  volume={312 17},
  pages={1764-71}
}
IMPORTANCE Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression. OBJECTIVE To evaluate whether genetic data are consistent with an association between LDL-C, high-density lipoprotein cholesterol (HDL-C), or triglycerides (TG) and aortic valve disease. DESIGN… CONTINUE READING