Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer

@article{Lu2012AssociationOL,
  title={Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer},
  author={Lingeng Lu and Guangjian Zhu and Chong Zhang and Qian Deng and Dionyssios Katsaros and Susan Taylor Mayne and Harvey A. Risch and Lina Mu and Emilie Marion Canuto and Gianluca Gregori and Chiara Benedetto and Herbert Yu},
  journal={Breast Cancer Research and Treatment},
  year={2012},
  volume={136},
  pages={875-883}
}
Large noncoding RNA HOTAIR, transcribed from the antisense strand of HOXC12, interacts with Polycomb Repressive Complex 2 (PRC2) in the regulation of gene activities. Recent work suggests that it may have effects on breast cancer progression and survival. We evaluated HOTAIR expression and the methylation status of its downstream intergenic CpG island in primary breast cancers, and examined associations of these factors with clinical and pathologic features and patient survival. HOTAIR… CONTINUE READING