Association of known loci with lipid levels among children and prediction of dyslipidemia in adults.

@article{Tikkanen2011AssociationOK,
  title={Association of known loci with lipid levels among children and prediction of dyslipidemia in adults.},
  author={Emmi Tikkanen and Tarja Tuovinen and Elisabeth Wid{\'e}n and Terho Lehtim{\"a}ki and Jorma Viikari and Mika K{\"a}h{\"o}nen and Leena Peltonen and Olli T. Raitakari and Samuli Ripatti},
  journal={Circulation. Cardiovascular genetics},
  year={2011},
  volume={4 6},
  pages={673-80}
}
BACKGROUND Recent genome-wide association studies have found 95 distinct genetic loci associated with high-density (HDL-C) and low-density (LDL-C) lipoprotein cholesterol, total cholesterol (TC), and triglycerides (TG), using adult samples. It is not known if these variants are associated with lipid levels in children and adolescents and if the genetic risk score (GRS), based on these variants, could improve adulthood dyslipidemia prediction over the childhood lipid measurements. METHODS AND… CONTINUE READING
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