Association of iron‐containing astrocytes with dopaminergic neurons of the arcuate nucleus

@article{Young1990AssociationOI,
  title={Association of iron‐containing astrocytes with dopaminergic neurons of the arcuate nucleus},
  author={J. K. Young and James C. McKenzie and John H. Baker},
  journal={Journal of Neuroscience Research},
  year={1990},
  volume={25}
}
Specialized astrocytes, identified by cytoplasmic granules that are electron‐dense and vividly stained by toluidine blue due to the presence in the granules of SH molecules and molecules of iron, have long been known to be present within the arcuate nucleus of the hypothalamus. Their function, however, is obscure. To determine whether or not these specialized astrocytes are in contact with dopaminergic neurons, rat brain sections were stained to detect tyrosine hydroxylase (TH) immunoreactive… 
Gomori‐positive astrocytes: Biological properties and implications for neurologic and neuroendocrine disorders
TLDR
Gomori‐positive astrocytes may supply heme to neurons for the synthesis of cytochromes, catalases, and other heme enzymes, and play a role in photostimulation of sexual cyclicity, the promotion of neuritic development, the degradation of toxic lipoperoxides, and the metabolism of various neurotransmitters.
GLUT2 Immunoreactivity in Gomori-positive Astrocytes of the Hypothalamus
  • John K. Young, J. McKenzie
  • Biology
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 2004
TLDR
The possibility that Gomori-positive astrocytes may have an important influence upon the reactivity of the hypothalamus to glucose and that a specialized glucose metabolism may in part underlie the development of mitochondrial abnormalities in hypothalamic GP astroCytes is supported.
Glial immunoreactivity for metallothionein in the rat brain
TLDR
A series of frozen and vibratome coronal sections of the rat brain were examined by immunocytochemistry for the presence of a cysteine‐rich metal binding protein, metallothionein, which represented a subset of MT‐positive astrocytes that may be involved in reactions to blood‐borne metal compounds that penetrate into circumventricular organs of the brain.
A Cellular Stress Model for the Sequestration of Redox‐Active Glial Iron in the Aging and Degenerating Nervous System
TLDR
The results of this study suggest that stress‐related trapping of nonheme iron by astroglial mitochondria may be an important mechanism underlying the pathological accumulation of redox‐active iron in the basal ganglia of subjects with Parkinson's disease.
Copper accumulation in rodent brain astrocytes: A species difference.
Immunoreactivity for brain‐fatty acid binding protein in gomori‐positive astrocytes
TLDR
Gomori‐positive (GP) astrocytes are a subset of brain astro cytoplasmic granules that arise from the degradation of mitochondria that can be detected in the olfactory bulbs, hippocampus, habenula, and other selected brain regions.
The brain response to 2-deoxy glucose is blocked by a glial drug
Neurogenesis Makes a Crucial Contribution to the Neuropathology of Alzheimer’s Disease
  • John K. Young
  • Biology, Psychology
    Journal of Alzheimer's disease reports
  • 2020
TLDR
Retrograde degeneration of neurons with axons terminating in the dentate gyrus provides a likely explanation for the spatial patterns of neuronal cell death seen in AD.
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