Association of interleukin 23 receptor variants with psoriatic arthritis.

@article{Rahman2009AssociationOI,
  title={Association of interleukin 23 receptor variants with psoriatic arthritis.},
  author={Proton Rahman and Robert D. Inman and Walter P. Maksymowych and Jeff P. Reeve and Lynette Peddle and Dafna D Gladman},
  journal={The Journal of rheumatology},
  year={2009},
  volume={36 1},
  pages={137-40}
}
OBJECTIVE A recent genome-wide pooling study noted a significant association of interleukin 23 receptor (IL-23R) and psoriasis. Overxpression of IL-23 has been detected in lesional psoriatic skin, and induces epidermal proliferation. Given the interplay between psoriasis and PsA, we examined the association of IL-23R variants in 2 independent Canadian Caucasian cohorts of patients with psoriatic arthritis (PsA). METHODS We examined 496 PsA probands and 476 controls. Cases and controls were… CONTINUE READING

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