Association of interleukin-18 gene promoter polymorphisms in type 1 diabetes and autoimmune thyroid disease.

Abstract

Type 1 diabetes is a heterogeneous autoimmune disease and is often associated with other organ-specific autoimmune diseases, including autoimmune thyroid disease (AITD). IL-18 is a potent proinflammatory cytokine capable of inducing IFN-gamma production that is associated with the development of type 1 diabetes and AITD. The gene for IL-18 is located near Idd2 and has been reported to be associated with a susceptibility to type 1 diabetes. To test the putative involvement of IL-18 gene polymorphism in predisposition to type 1 diabetes and AITD, we conducted a case-control study in Japanese population. The SNPs at position -607 (C/A) and -137 (G/C) in the promoter region of the IL-18 gene were analyzed by sequence-specific PCR in 74 nondiabetic patients with AITD, 47 type 1 diabetic patients with AITD, and 114 normal controls. There was no significant increase in the genotype and allele frequencies not only in nondiabetic patients with AITD compared with normal controls, but also in type 1 diabetic patients with AITD compared with normal controls. The distribution of IL-18 gene haplotypes was also similar between both patient groups and normal controls. These results suggest that polymorphisms of the IL-18 gene are not associated with a susceptibility to AITD and type 1 diabetes coexistent with AITD in Japanese population.

Cite this paper

@article{Ide2003AssociationOI, title={Association of interleukin-18 gene promoter polymorphisms in type 1 diabetes and autoimmune thyroid disease.}, author={Akane Ide and Eiji Kawasaki and Norio Abiru and Fuyan Sun and Tetsuya Fukushima and Reiko Ishii and Ryoko Takahashi and Hironaga Kuwahara and Naruhiro Fujita and Atsushi Kita and Misa Imaizumi and Katsuya Oshima and Toshiro Usa and Shigeo Uotani and Eri Ejima and Hironori Yamasaki and Kiyoto Ashizawa and Yoshihiko Yamaguchi and Katsumi Eguchi}, journal={Annals of the New York Academy of Sciences}, year={2003}, volume={1005}, pages={436-9} }