Association of interleukin-17A polymorphisms with the risk of colorectal cancer: A case-control study.

BACKGROUND Interleukin (IL)-17A is proinflammatory cytokine produced by Th17 cells, which play key, but sometimes inconsistent role in autoimmunity and cancer. Polymorphic variants in IL-17A gene were differentially associated with susceptibility to cancer, including colorectal cancer (CRC). AIM We investigated the association between six IL-17A gene… CONTINUE READING