Association of interleukin-1 receptor antagonist gene polymorphisms with early onset periodontitis in Japanese.

@article{Tai2002AssociationOI,
  title={Association of interleukin-1 receptor antagonist gene polymorphisms with early onset periodontitis in Japanese.},
  author={Hideaki Tai and Motohiro Endo and Yasuko Shimada and Emire Gou and Kazuko Orima and Tetsuo Kobayashi and Kazuhisa Yamazaki and Hiromasa Yoshie},
  journal={Journal of clinical periodontology},
  year={2002},
  volume={29 10},
  pages={
          882-8
        }
}
BACKGROUND/AIMS Early onset periodontitis (EOP), newly 'aggressive periodontitis', is considered to have genetic basis, which have not been clearly defined. The interleukin-1 (IL-1) gene cluster polymorphism as one of genetic factors may influence the expression of several chronic inflammatory diseases. The aim of this study is to investigate the frequency of single nucleotide polymorphisms (SNPs) in the genes encoding IL-1alpha, IL-1beta and a variable number of tandem repeat (VNTR… CONTINUE READING
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