Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: the Honolulu-Asia Aging Study.

@article{Yucesoy2006AssociationOI,
  title={Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: the Honolulu-Asia Aging Study.},
  author={Berran Yucesoy and Rita L Peila and Lon R. White and Kim Ming Wu and Victor Johnson and Michael L. Kashon and Michael I. Luster and Lenore J. Launer},
  journal={Neurobiology of aging},
  year={2006},
  volume={27 2},
  pages={211-7}
}
The interleukin-1 (IL-1) pro-inflammatory cytokine family participates in inflammatory processes and vessel damage involved in neurodegeneration. Recent studies suggest that Alzheimer's disease (AD) and vascular dementia (VaD) may share genetic risk factors. In this study, the frequency of polymorphisms in the genes coding for interleukin (IL)-1alpha, IL-1beta and the IL-1 receptor antagonist (RN) and their genotype associations with late-onset AD and VaD were determined in a Japanese-American… CONTINUE READING

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